Publications
For an up-to-date list of publications, see Dr. McDiarmid’s Pubmed or Google Scholar
22. McDiarmid, T. A.*, Page, N. F.*, Chardon, F. M.* Daza, R. M., Chen, G. T., Kosicki, M., James, L. M., Nourie, H. C., Laboy-Cintrón, D., Lee, A. S., Vij, P., Calderon, D., Lalanne, J.B., Martin, B.K., Fink, K., Talkowski, M. E., Muotri, A. R., Philpot, B. D., Pennacchio, L. A., Geschwind, D. H., Sanders, S. J., Ahituv, N.†, Shendure, J.† Large-scale discovery of neural enhancers for cis-regulation therapies. bioRxiv, 2025.
21. Lalanne, J. B.†, Mitch, J. K., Huynh, C., Hunker, A. C., McDiarmid, T. A., Levi, B. P., Ting, J. T., Shendure, J.† Extensive length and homology dependent chimerism in pool-packaged AAV libraries. Accepted at Nature Biotechnology, bioRxiv, 2025.
20. Chardon, F. M.†, Suiter, C. C., Daza, R. M., Smith, N. T., Parrish, P., McDiarmid, T. A., Lalanne, J. B., Martin B. K., Ellison A., Calderon, D., Berger, A. H.†, Shendure, J.†, Starita, L. M.† A multiplex, prime editing framework for identifying drug resistance variants at scale. Cell Genomics, 2026.
19. McDiarmid, T. A.*,†, Taylor, M. L.*, Chen, W., Chardon, F., Choi, J., Liao, H., Li, X., Kim, H., Lalanne, J. B., Li, T., Nathans, J. F., Martin, B. K., Knuth, J., Coradini, A. L. V., Gray, J. M., Pinglay, S., Shendure, J.† A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording. Nature Biotechnology, 2025.
18. Nathan, J. F.*, Chen, W.*,†, McDiarmid, T. A.*,†, Shendure, J.† Multichannel Genomic Recording of Biological Information with ENGRAM. Nature Protocols, 2025.
17. Ho, C.H., Dippel, M., McQuade, M., Nguyen, L., Mishra, A., Pribitzer, S., Hardy, S., Chandok, H., Chardon, F. M., McDiarmid, T. A., DeBerg, H. A., Buckner, J. H., Shendure, J., de Boer, C., Guo, M. H., Tewhey, R., Ray, J. P.† Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks. Nature Genetics, 57(10):2536-2545, 2025.
16. Chardon, F. M.*, McDiarmid, T. A.*, Page, N. F., Daza, R. M., Martin, B. K., Domcke, S., Regalado, S. G., Lalanne, J. B., Calderon, D., Li, X., Starita, L. M., Sanders, S. J., Ahituv, N.†, Shendure, J.† Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements. Nature Communications, 15(1):8209, 2024.
15. Li, X., Chen, W., Martin B. K., Calderon, D., Lee, C., Choi, J., Chardon, F. M., McDiarmid, T. A., Daza, R. M., Kim, H., Lalanne, J. B., Nathans J. F., Lee, D. S., Shendure, J. Chromatin context-dependent regulation and epigenetic manipulation of prime editing. Cell, 187(8):1-17, 2024.
14. The Impact of Genomic Variation on Function (IGVF) Consortium, Deciphering the impact of genomic variation on function. Nature, 633(8028):47-57, 2024.
13. Kepler, L. D.*, McDiarmid, T. A.*, Rankin, C.H. Rapid assessment of the temporal function and phenotypic reversibility of neurodevelopmental disorder risk genes in Caenorhabditis elegans. Disease Models & Mechanisms, 15(5):049359, 2022.
12. Kepler, L. D. M, McDiarmid, T. A., & Rankin, C. H. Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. Neurobiology of Learning and Memory, 171:107208, 2021.
11. Post, K. L.*, Belmadani, M.*, Ganguly, P.*, Meili, F.*, Dingwall, R.*, McDiarmid, T. A.*, Meyers, W. M., Herrington, C., Young, B. P., Callaghan, D. B., Rogic, S., Edwards, M., Niciforovic, A., Cau, A., Rankin, C. H., O’Connor, T. P., Bamji, S. X., Loewen, C. J., Allan, D. W., Pavlidis, P.†, & Haas, K.† Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction. Nature Communications, 11(11):2073, 2020.
10. McDiarmid, T. A., Belmadani,M., Liang,J., Meili,F., MathewsE. A., MullenG.P., Hendi, A., Wong, W. R., Rand,J. B., MizumotoK., Haas K., PavlidisP., & Rankin, C. H. Systematic phenomics analysis of Autism-associated genes reveals parallel networks underlying reversible impairments in habituation. PNAS, 117(1), 656-667, 2020.
9. McDiarmid, T. A., Au, V., Moerman D. G., & Rankin, C. H. Peel-1 negative selection promotes screening-free CRISPR-Cas9 genome editing in C. elegans. PLOS ONE,15(9):e0238950, 2020.
8. McDiarmid, T. A., Au, V., Moerman D. G., & Rankin, C. H. Auxin does not affect a suite of morphological or behavioral phenotypes in two wild-type C. elegans strains. Micropublication Biology,10:17912, 2020.
7. McDiarmid, T. A., Yu, A. J., & Rankin, C. H. Habituation is more than learning to ignore: multiple mechanisms serve to facilitate shifts in behavioral strategy. BioEssays, 41(9), e1900077, 2019.
6. McDiarmid, T. A., Au, V., Loewen, A. D., Liang, J., Mizumoto, K., Moerman, D. G., & Rankin, C. H. CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance. Disease Models & Mechanisms, 11(12), dmm036517, 2018.
5. Yu, A. J.*, McDiarmid, T. A.*, Ardiel, E. L., & Rankin, C. H. High-throughput analysis of behavior under the control of optogenetics in Caenorhabditis elegans. Current Protocols in Neuroscience, 86(1), e57, 2018.
4. Ardiel, E. L.*, McDiarmid, T. A.*, Timbers, T. A.*, Lee, K. C., Safaei, J., Pelech, S. L., & Rankin, C. H. Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in Caenorhabditis elegans. Proceedings of the Royal Society B: Biological Sciences, 285(1891), 20182084, 2018
3. McDiarmid, T. A., Yu, A. J., & Rankin, C. H. Beyond the response—high throughput behavioral analyses to link genome to phenome in Caenorhabditis elegans. Genes, Brain and Behavior, 17(3), e12437, 2018.
2. McDiarmid, T. A., Bernardos, A. C., & Rankin, C. H. Habituation is altered in neuropsychiatric disorders—A comprehensive review with recommendations for experimental design and analysis. Neuroscience & Biobehavioral Reviews, 80, 286-305, 2017.
1. McDiarmid, T. A., Ardiel, E. L., & Rankin, C. H. The role of neuropeptides in learning and memory in Caenorhabditis elegans. Current Opinion in Behavioral Sciences, 2, 15-20, 2015.